A Prospective Observational Study on Drug Utilization Pattern and Relation of Alcohol Consumption in Patients with Alcoholic Liver Disease in a Tertiary Care Hospital
Authors: Ganesh Nayak, Cyril Tom, Ditty Molukalayil Skaria, Ditty Molukalayil Skaria, Nehla Yasmeen, Fathima Hasbin CK
Indian Journal of Pharmacy Practice, Vol. 15, Issue 1, pp. 15-21, (2022)
DOI: 10.5530/ijopp.15.1.4
Abstract
Alcoholic Liver Disease is a result of excessive consumption of alcohol and alcohol containing beverages that damages the liver, leading to a buildup of fats, inflammation, and scarring.Objectives:The main aim of our study is an assessment of drug utilization patterns and the relation of alcohol consumption in ALD patients.Methods:A prospective type of observational study in a 700 bedded multispecialty hospital for 6 months. SPSS (Statistical Package for Social Science) version 20. [IBM SPASS statistics (IBM corp. Armonk, NY, USA released 2011)] was used to perform the statistical analysis. Drug therapy and amount, duration and binge of alcohol consumption were assessed.Results:Majority of them consuming alcohol to a greater amount for 10-20 years. A total of 588 drugs were prescribed to 65 patients. Out of which most commonly prescribed class of drug was proton pump inhibitors, followed by vitamins, antibiotics, and diuretics. The commonly prescribed vitamins, antibiotics and diuretics, hepatoprotective agent were, Vit K(44.6%), Rifagut (rifaximin)(58.5%) and spironolactone(50.8%), pentoxyfyllin (4.6%) respectively.Conclusion:The main causes of the patient’s lower quality of life are excessive alcohol consumption and noncompliance with the prescribed treatment. All of these factors will exacerbate the disease. To improve their condition and control ALD, patients should abstain from alcohol and strictly adhere to their medication regimen. The patient should be educated enough about the disease and the adherence to medication so that they might be able to upgrade their status of life and be disease free.
Keywords: Alcoholic liver disease, Fatty liver, Cirrhosis, Alcohol, Drug utilization, Evaluation
