A Study on Antimicrobial Evaluation of Different Generic and Branded Tablet of Ciprofloxacin HCl Marketed in Wardha District

Abstract

Bacterial infection is responsible for various activity including respiratory, urinary tract, gastrointestinal and abdominal infections. Ciprofloxacin HCl, a second-generation fluroquinolone antibiotic that can treat a number of bacterial infections. The aim of this work was to evaluate antimicrobial activity of different generic and branded drug formulation marketed in Wardha district. i.e. Cifran and Zoxan. All the formulations obtained from the market were in compliance with the control samples in respect of Preformulation study, Disintegration,in vitrodrug release, and antimicrobial potential. Thus, the antimicrobial activity of marketed and control sample was also same shows satisfactory results againstStaphylococcus aureusas compare toEscherichia coli,butStaphylococcus aureuswas shows better microbiological assay response as compare toE. coli.

Keywords: ciprofloxacin; bacterial infections; antimicrobial activity; drug formulations