Acute Nitrobenzene Poisoning with Severe Methemoglobinemia: ACase Report
Authors: Hisham Md., Vijayakumar A, Rajesh N, Sivakumar M.N
Indian Journal of Pharmacy Practice, Vol. 5, Issue 4, pp. 84-86, (2012)
Abstract
Introduction: Nitrobenzene, an aromatic organic compound used in paints and printing industry. Its toxicity induces methemoglobinemia. Clinical Sequelae: A42 year female patient survived a suicidal consumption of 250ml of 20% Nitrobenzene. On presentation to the hospital, the patient was unconscious and showed typical signs of cyanosis, abnormal arterial blood gas (ABG) showing metabolic acidosis with SpO of 83%, 2 and the arterial blood sample was chocolate brown in colour. The patient suspected of methemoglobinemia showed the formation of 17.7% methemoglobin (normal: 0-2 % of Hb). Management: She underwent supportive treatment and was given 1% methylene blue and 1gm ascorbic acid which acts as an oxygen scavenger. The patient eventually made a complete recovery and the ABG was entirely normalized after 17 days due to intensive treatment. Conclusion: Acute Methemoglobinemia is usually associated with high mortality; hence early identified and aggressive management of poisoning should be attempted. RBC exchange transfusion and hyperbaric oxygen therapy are usually reserved for patients who are resistant to standard treatment.
Keywords: Ascorbic Acid, Cyanosis, Methylene Blue, Nitrobenzene, Methemoglobinemia, ABG
