Toxic Epidermal Necrolysis induced by Phenytoin: A Case Study
Authors: Manoj Kumar M, Yogendra M, Karthik M, Gowthami B, Yogananda R, Bharathi DR
Indian Journal of Pharmacy Practice, Vol. 7, Issue 2, pp. 37-39, (2014)
DOI: 10.5530/ijopp.7.2.8
Abstract
Toxic epidermal necrolysis (TEN) is severe adverse cutaneous drug reaction that predominantly involves the skin and mucous membranes. It is usually induced by medications. Anti-convulsants such as phenytoin, carbamazepine and phenobarbital have been enlisted as high risk drugs for causing TEN. Objectives: The main objective of this case report is to evaluate the importance of detection, assessment and reporting of an adverse drug reaction and to improve the medication adherence. Methods: This is an observational type of case report which we observed in our hospital on regular ward rounds. Results: This is a case report of Toxic epidermal necrolysis due to a Phenytoin which was used in the treatment of epilepsy in a 25 year old female patient. Causality assessment of the event with Naranjo’ scale suggest “Probable”. Conclusion: Proper counselling to the patient regarding the use of medications is of utmost importance, in such life threatening conditions where treatment guidelines remain hazy.
Keywords: Adverse drug reaction, Toxic epidermal necrolysis, Phenytoin
