Assessment of Antibiotic Efficacy in the Management of “Priority 1: Critical” Multi-Drug Resistant Gram-Negative Bacterial Infections Enlisted by WHO
Authors: Morey Komal M, Ramaiah Balakeshwa, Prabhudev B. R
Indian Journal of Pharmacy Practice, Vol. 18, Issue 1, pp. 71-83, (2024)
Abstract
Background:The growing resistance pattern ofmultidrug-resistant gram-negative bacteria is increasing, making it more crucial to use antibiotics. Our study focuses on antibiotics’ rational use and efficacy for gram-negative bacterial infections. aim to find the susceptibility and the resistance pattern of the gram-negative bacteria-P. aeruginosa, K. pneumoniae, A. baumannii, andE. coli(Priority 1: Critical) to the antibiotics and to assess the antibiotic efficacy.Materials and Methods:It is a prospective observational study performed using an antibiogram to find susceptibility and the right use of the antibiotic for Priority 1: Critical species of gram-negative bacteria. The study involved 201 people and was carried out over a period of nine months. Statistical analysis was performed with the help of JASP software.Results:Escherichia colibeing the highest gram-negative causing bacterial infections have also made it very challenging to treat the infections due to its growing resistance pattern. our study showed that Cefoperazone+sulbactam and piperacillin+tazobactam are the most susceptible drugs. The highest-resistant drugs are carbapenem, meropenem, ampicillin and ertapenem. Student-paired T-test was performed for CRP, Procalcitonin and ESR; the results were statistically significant.Conclusion:This study interprets the growing and new pattern of MDR that has made it a very challenging aspect of the healthcare system. It emphasizes the appropriate usage of antibiotics for better infection control and good patient outcomes.
Keywords: MDR bacterial infection, Gram-negative bacterial infection, Antibiotic in MDR, JASP software
