Augmentin Induced Exfoliative Dermatitis: Case Report
Authors: Ashish Karn, Juie Shah, Rutuva Shah, Riki Patel, Bhavya Modi
Indian Journal of Pharmacy Practice, Vol. 15, Issue 1, pp. 137-139, (2022)
Abstract
Exfoliative dermatitis is a very rare form of drug induced hypersensitivity reaction which usually involves skin and mucous membrane, can be seen from a few days to several weeks after the administration of drug.1 Amoxicillin is a broad spectrum antibiotic, belongs to class amino-penicillin of beta-lactum antibiotics, and it is generally active against gram-positive bacteria, gram-negative bacteria and anaerobes which represent the major species present in the stomach, biliary tract and colorectum. Therefore, it is a preferred choice as a prophylaxis for abdominal surgery. It is usually combined with clavulanic acid which is a beta-lactamase inhibitor, in order to maintain greater efficacy and activity against beta-lactamase-positive strains.2 Here is a case of delayed type of hypersensitivity reaction of a 58 years old female who developed multiple erythematous scaly plaques with erosion sign and exfoliation of skin seen all over the four limbs following the administration of Augmentin.
Keywords: Augmentin, Erythoderma, Exfoliative Dermatitis, Delayed Hypersensitivity, Aminopenicillin, Severe cutaneous reaction
