The Role of Finasteride in the Management of Androgenetic Alopecia in Male: A Narrative Review
Authors: Anil Tumkur, Charmine Caryn Teo Cher Ern, Chang Ching Shuang, Amilia Chai Hui Yong, Chan Poh Yee, Chai Tze Leen, Lee Kah Lock, Nermesh Singh
Indian Journal of Pharmacy Practice, Vol. 13, Issue 1, pp. 3-13, (2020)
DOI: 10.5530/ijopp.13.1.2
Abstract
The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibitor in the prevention and treatment of androgenetic alopecia (AGA) in males. Finasteride inhibits 5α-reductase and reduce the biosynthesis of dihydrotestosterone (DHT). This inhibition marks a decrease in concentration of DHT and provides a novel and selective approach to androgen deprivation. Clinical trials have proven the safety and efficacy of tablet finasteride 1 mg for AGA. In this review, we discuss all aspects of finasteride, including dosing and indication, pharmacology, pharmacokinetics to its role in the treatment of AGA.
Keywords: Androgenic alopecia, DHT, Finasteride, Norwood-Hamilton scale, Safety.
