The purpose of this review was to evaluate the role of finasteride, a type-II 5α-reductase inhibitor in the prevention and treatment of androgenetic alopecia (AGA) in males. Finasteride inhibits 5α-reductase and reduce the biosynthesis of dihydrotestosterone (DHT). This inhibition marks a decrease in concentration of DHT and provides a novel and selective approach to androgen deprivation. Clinical trials have proven the safety and efficacy of tablet finasteride 1 mg for AGA. In this review, we discuss all aspects of finasteride, including dosing and indication, pharmacology, pharmacokinetics to its role in the treatment of AGA.
Key words: Androgenic alopecia, DHT, Finasteride, Norwood-Hamilton scale, Safety.