Sulfamethoxazole+Trimethoprim Induced Stevens- Johnson Syndrome in HIV Patient: A Case Report

Published on:September 2019
Indian Journal of Pharmacy Practice, 2019; 12(4):283-285
Case Report | doi:10.5530/ijopp.12.4.60

Sulfamethoxazole+Trimethoprim Induced Stevens- Johnson Syndrome in HIV Patient: A Case Report

Authors and affiliation (s):

Manjunath Gandage*, Gayathri Panumetcha, Neelkanthreddy Patil , Pooja Salimath, Harish Kumar, Sheetal Ninne

Department of Pharmacy Practice, Basaweshwar Teaching and General Hospital, HKES’s College of Pharmacy (MTRIPS), Sedam Road, Gulbarga, Karnataka, INDIA.


Stevens-Johnson syndrome is mucocutaneous cellmediated hypersensitivity reaction which affects 2 to 3 cases per million. SJS is generally rare, but potentially lifethreatening and commonly drug induced. Trimethoprimsulfamethoxazole (TMP/SMX) is a widely prescribed antimicrobial for the management of several uncomplicated infections. It is commonly used for the treatment and prophylaxis of Pneumocystis Jirovecii Pneumonia (PCP) in the HIV-infected population. The adverse reaction to TMP/SMX is more frequent and severe in HIV-infected patients as compared to the general population. We report a case of 39-year-old male patient admitted into male medical free ward with a chief complaints of fever, difficulty in swallowing, skin lesions over the body from 4 days. Multiple well-defined erythematous macules, Erosion and crustations on angle of the mouth, Genital Involvement, Acute Conjuctivitis are observed. These clinical manifestations are observed after taking sulfamethoxazole+trimethoprim on 5th day. Based on the above clinical investigations it is diagnosed as sulfamethoxazole+trimethoprim induced Stevens-Johnson syndrome.

Key words: Stevens-Johnson syndrome, Sulfamethoxazole+trimethoprim, HIV, ADR.


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