Type 2 Diabetes Patients on Dual Oral Therapy: Does Glycemic Control Continue to Deteriorate in these Patients?

Published on:
Indian Journal of Pharmacy Practice, 2014; 7(1):41-46
Research Article | doi:Nill


Type 2 Diabetes Patients on Dual Oral Therapy: Does Glycemic Control Continue to Deteriorate in these Patients?


Authors and affiliation (s):

Sirajudeen S A*1, Dhanapal C K 2, Noodhu A K1, Daniel S P1, Venkatachalam V V2, Khaled M A1

1Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, K.S.A

2Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram.

Abstract:

Objectives: The objective of this retrospective analysis was to evaluate the glycemic control and cardiac parameters in patients with type 2 diabetes mellitus who were prescribed dual oral therapy after the failure of diet, exercise and metformin monotherapy. Methods: Type 2 diabetics patients who were added a second oral agent to the previous metformin monotherapy at least 3 months prior to the baseline visit were followed during June 2012 to June 2013. Data collected from the patient files included demographic characteristics, medical history, physical examination findings, diabetes related laboratory measurements and treatment recommendations in each visit. The patients were followed up in a scheduled manner every three months and the above data were recorded in each visit. Results: A total of 61 patients with a mean age of 54.8 ± 10.7 years participated in the study. During the study, HbA1c declined in the first visit and then started to increase gradually. Only 32.8% of patients achieved HbA1c ≤7%. The fasting blood sugar escalated gradually from the baseline to the fourth visit and only 13.1% of patients achieved ≤110 mg/dl. There was no marked change in the blood pressure, body weight and BMI. There was insignificant reduction in the total cholesterol and triglyceride level and there was no marked change in LDL, HDL and VLDL. Conclusion: Our findings suggest that the progressive deterioration of HbA1c observed while patients were treated with dual oral therapy and highlights the importance of aggressive monitoring and prompt intervention to improve glycemic control in type 2 diabetes patients

Keywords: BMI, Body Weight, Fasting Blood Sugar, Glycemic Control, HbA1c, Type 2 diabetes mellitus.




 

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmacy Practice (IJOPP) [ISSN-0974-8326] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 2008.

DOI HISTORY

IJOPP uses reference linking service using Digital Object Identifiers (DOI) by Crossref. Articles from the year 2014 are being assigned DOIs for its permanent URLs