Churg-Strauss syndrome (CSS) is a rare disorder that affects medium to small sized vessels, multiple organ systems especially the lungs. The disorder is characterized by hypereosinophilia in the blood and tissues, inflammation of blood vessels (vasculitis) and the development of inflammatory nodular lesions called granulomas (granulomatosis). This report refers to a 72 year old female patient presented with sudden and abrupt onset of asthma and breathlessness with other complaints of peripheral neuropathy and generalised weakness. Laboratory investigation showed her to be hypereosinophilic, positive p-ANCA (perinuclear Anti-Neutrophil Cytoplasmic Antibodies) and nerve biopsy revealed vasculitis. We report a case on Churg Strauss Syndrome with hypereosinophila, vasculitis and asthma, effectively treated with corticosteroid and immunosuppressant.
Key words: Churg Strauss Syndrome, Asthma, p-ANCA, Vasculitis, Granulomatosis, Hypereosinophilia, Corticosteroids, Immunosuppressant.