Trigger Tool Based Detection of Adverse Drug Reactions in a Tertiary Care Teaching Hospital: A Prospective Observational Study

Published on:September 2018
Indian Journal of Pharmacy Practice, 2018; 11(3):111-115
Review Article | doi:10.5530/ijopp.11.3.25


Trigger Tool Based Detection of Adverse Drug Reactions in a Tertiary Care Teaching Hospital: A Prospective Observational Study


Authors and affiliation (s):

Raja Sree Gadde1, Divya Teja Dhanenkula1, Sowjanya Kammila1, Dharani Nelluri1, Manjusha Polisetty1, Sowmya Kaniganti3, Yamini Vadlamannati3, Siva Reddy Challa2,*  Lakshmi Pavani Anne1, Krishna Sri Nalla2, Sravya Gethika Dammalapati1


1Department of Pharmacy Practice, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520 010, Andhra Pradesh, INDIA.

2Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520 010, Andhra Pradesh, INDIA.

3Department of Pharmacology Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinoutpalli, Gannavaram, Krishna, Andhra Pradesh, INDIA.

Abstract:

Background: The use of “triggers” to identify Adverse Drug reactions (ADRs) is a novel emerging method for measuring the overall level of harm from medications in a health care organization. Our main objective is to determine the incidence of adverse drug reactions in the hospitalized patients and to compare Global Trigger Tool (GTT) with conventional method to identify ADRs. Methodology: A Prospective observational study was conducted over a period of six months during November 2016-April 2017. Modified Global Trigger Tool was used to identify triggers. 16 triggers were used to identify ADRs. Causality assessment of ADRs was done using Naranjo scale and severity and harm categorization of ADRs were assessed using NCC MERP. Results: A total of 244 patient profiles were analyzed. The results reveal that 193 triggers were identified in 125 patients and 93 ADRs were found in 81 patients. Out of which, 64(68.81%) ADRs were found by triggers and 29(31.18%) ADRs were found spontaneously without the presence of a trigger. There is a remarkable improvement in the identification of ADRs using trigger tool in comparison to traditional approach. Of 93 ADRs identified, 69 (74.19%) were probable and 24 (25.81%) were possible. Similarly, 65 (69.89%) were determined to be NCC-MERP harm category E and 28 (30.11%) were category F. Conclusion: The study results suggest that IHI global trigger tool could be useful to identify ADRs in hospitals twice as more efficiently when compared to traditional ADR identification methods. It is an effective method to enable clinical pharmacists to identify ADRs and management of the same.

Key words: Adverse drug reactions (ADRs), IHI global trigger tool, NCC-MERP harm category, Causality, Prospective, Naranjo scale.



 

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
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Indian Journal of Pharmacy Practice (IJOPP) [ISSN-0974-8326] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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