Gingival Overgrowth on Chronic use of Amlodipine: A Case Report

Published on:x
Indian Journal of Pharmacy Practice, 2017; 10(4):x
x | doi:10.5530/ijopp.10.4.xx


Gingival Overgrowth on Chronic use of Amlodipine: A Case Report


Authors and affiliation (s):

Muhammed Rashid Parambil Peedikkal1, Juny Sebastian1*, Madhan Ramesh1, Narayanappa Doddaiah2, Sathya Narayana Prashanth2

1Department of Pharmacy Practice, JSS College of Pharmacy, Jagadguru Shri Shivarathreeshwara University, S S Nagara, Mysuru, INDIA.

2Department of Paediatrics, JSS Medical College and Hospital, Jagadguru Shri Shivarathreeshwara University, S S Nagara, Mysuru, INDIA.

Abstract:

Background: Amlodipine, a calcium channel blocker (CCB) which is a commonly prescribed antihypertensive medication. Nifedipine is the CCB which is most frequently associated with drug induced gingival overgrowth. Case report: A 9 year old girl presented to the out-patient department of the hospital with the complaints of swelling of left side of cheek with mild to moderate grade pain since 5-6 days.The pain increased on touching and during jaw movements. Her past medical history revealed that she was a known case of cardiomyopathy with bilateral renal artery stenosis with hypertension and was on oral medications amlodipine (5 mg BD), furosemide (40 mg BD) and carvedilol (3.125 mg BD) for the past three years. She was diagnosed as having gingival overgrowth induced by the use of amlodipine. The gingival overgrowth was managed with dental extraction, drainage of abscess and gum cartilage following the withdrawal of the offending drug amlodipine. Alternatively she was started on oral prazosin (1 mg BD) along with other regular medications. Conclusion: Though the incidence of amlodipine causing the gingival overgrowth is less when compared to other drugs in the CCB class, the patients have to be monitored for the gingival overgrowth when on chronic use.

Key words: Amlodipine, Calcium channel blocker, Gingival overgrowth, Gum hyperplasia.




 

The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
(Registered under Registration of Societies Act XXI of 1860 No. 122 of 1966-1967, Lucknow)

Indian Journal of Pharmacy Practice (IJOPP) [ISSN-0974-8326] is the official journal of Association of Pharmaceutical Teachers of India (APTI) and is being published since 1967.

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