Evaluation of Antimalarial Drug use in Tertiary Care Teaching Hospital

Published on:November 2017
Indian Journal of Pharmacy Practice, 2017; 10(3):201-206
Research Article | doi:10.5530/ijopp.10.3.41

Evaluation of Antimalarial Drug use in Tertiary Care Teaching Hospital

Authors and affiliation (s):

Anushree Shrikant Deshpande1*, Mallappa Hanamantappa Shalavadi2, Harshitkumar Bhupendrabhai Patel2, Arvind Dayalbhai Vasoya2, Rahul Kotwal3, Chandrashekhar VM2

1Assistant Professor, Department of Pharmacy Practice, KLE University’s College of Pharmacy, Belagavi, Karnataka, INDIA.

2Department of Pharmacy Practice, H.S.K College of Pharmacy, Bagalkot, Karnataka, INDIA.

3Medical Advisor, Department of Medical Affairs, Macleods Pharmaceuticals Ltd., Andheri East, Mumbai, Maharashtra, INDIA.


Background: Malaria is a major cause of morbidity and mortality in the developing countries. Rational use of antimalarial drugs reduces the development of drug resistance and cost of therapy. Hence, we sought to evaluate the use of antimalarial drugs. Aim: The study was designed to evaluate the use of anti-malarial drugs in in-patient admission of medicine and pediatrics department at tertiary care teaching hospital. Methods: The data was obtained prospectively from 98 patients with antimalarial drugs over a period of 6 months. The evaluation was assessed based on age, pattern of malarial parasite, therapy and rationality of prescription. Results: The demographic details of patients admitted in hospital showed more male patients (60.52%) than children’s (19.48%) and this reflects that the prevalence of the disease was higher among adult patients in this region during the study. Out of 98 patients prescribed with antimalarial drugs, only 46 patients showed malarial infection and 52 patients were diagnosed with non-malarial infection. In this study three drug combination therapy was prescribed more (30.61%) followed by two drugs combination. Rationality of antimalarial drug prescription was assessed by NVBDCP out of which 45.65% and 82.69% were irrational respectively. Conclusion: In this study it was found that inappropriate use of antimalarial drugs was higher among patients with plasmodium falciparum and non-malarial patients. Cost of therapy was very high and thus it contributed to the economic burden on patients. Irrational prescriptions were high which indicated non-adherence to guidelines. Hence it concludes that educating the health professional for rational drug use as well as reducing the cost of therapy is essential.

Key words: Antimalarial, Rationality, Drug interaction, Cost effective analysis.


The Official Journal of Association of Pharmaceutical Teachers of India (APTI)
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